A large number of healthcare professionals are needed to support COVID-19 vaccination efforts nationwide. These healthcare professionals are essential to ensuring the American population is vaccinated safely as soon as possible. They play critical roles in proper vaccine storage, handling, preparation, and administration, and they must be prepared to respond to vaccine recipients’ questions and concerns. It is important these healthcare professionals receive the training needed to effectively meet the demands of their roles. Training must be ongoing as new COVID-19 vaccines become available and as vaccine recommendations evolve when we learn more about the vaccines and how to improve the vaccination process